Pure Encapsulations O.N.E. Multivitamin - Once Daily Multivitamin with Antioxidant Complex Metafolin, CoQ10, and Lutein to Support Vision, Cognitive Function, and Cellular Health* - 60 Capsules
Multivitamin for Women & Men: Once-daily capsules provides vitamins A, B, C, D and E in highly bioavailable forms; CoQ10, L-5-MTHF, and ALA for antioxidant support* Cognitive Support Multivitamin: O. N.
Resar evidence panel
0–100 · cited research only
Evidence Score
62
Good
Safety Score
66
Good
Effectiveness Score
53
Emerging
Research Confidence
77
Strong
Product Fit Score
45
Emerging
Bottom line
Moderate evidence (Good) — promising research, but read the caveats before buying.
Product fit is weaker — dose, price, or practical use may not align with what studies tested.
Evidence Score
62
Good
Price
$48.50
Resar may earn an affiliate commission on this purchase. Commissions never change scores — see our affiliate disclosure and conflicts policy. Scores reflect cited research, not medical advice.
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The strongest studies behind this product
Ranked by evidence hierarchy and how closely each study matches this product. Start with the strongest study, then read down. Every claim needs a trail.
Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS
Meta Analysis · The American Journal of Clinical Nutrition · 2024
What the research shows
Modest preservation of cognitive scores versus placebo
Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: a randomised controlled trial
Randomized Controlled Trial · Nutrition Journal · 2007
Can taking a daily multivitamin improve cognitive performance in the elderly? Evidence from a steady state visually evoked potential investigation of memory in elderly women
Other · International Journal of Psychophysiology · 2010
Multivitamin and mineral supplement did not alter the antioxidant capacity in plasma of healthy young men and women
Other · Nutrition Research · 2000
Metabolic and Cognitive Outcomes of Subchronic Once-Daily Intranasal Insulin Administration in Healthy Men
Other · Frontiers in Endocrinology · 2018
Scores reflect these cited studies, not medical advice. Expand the full evidence detail below for protocols, dose context, and reported side effects.
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Claim ledger
Every claim, mapped to its source
Each product claim below is tied to a specific paper with study type, match strength, and limitations. Nothing here is medical advice — it is a research trail you can audit.
Claim match reflects how closely a specific paper supports this benefit — not AI confidence or medical certainty.
Full evidence detail
Study-by-study breakdown
Each paper below is ranked for this listing. Start with the highest match, then expand any study for a plain-language readout.
How to read this section
- Match % - how closely the study matches this product (not overall scientific quality).
- Evidence type - study design (RCT, review, etc.) and whether it is direct, category-level, or indirect.
- What it found - short summary and quoted extract from the paper metadata. Not medical advice.
In plain language
What the study reported
Verified extract — not AI generated
“Modest preservation of cognitive scores versus placebo”
One capsule daily as used in the trial
No serious adverse events reported
Caveats
Combines heterogeneous substudies; individual effect sizes modest; adherence details limited
Transparency
Score history
Human review is pending for this listing.
Reviews
Shopper feedback
4.6
average rating
10,685 Amazon reviews were available from the listing metadata.