BioActive Vitamin B12 5000 mcg | 3 BioActive Forms Plus Methylfolate Cofactor - Methylcobalamin, Adenosyl & Hydroxy | Sublingual Liquid Drops, Berry Flavor, Organic, Non-GMO, Vegan (1 oz)
Full-Spectrum Vitamin B12 - Plus Methyl Folate Cofactor: Methylcobalamin, Adenosylcobalamin & Hydroxocobalamin are the 3 most beneficial forms of Vitamin B12, with each having differing functions in the body. They are naturally occurring, biologically...
Resar evidence panel
0–100 · cited research only
Evidence Score
59
Good
Safety Score
72
Strong
Effectiveness Score
52
Emerging
Research Confidence
76
Strong
Product Fit Score
43
Emerging
Bottom line
Limited evidence (Good) — treat claims cautiously and review sources directly.
Product fit is weaker — dose, price, or practical use may not align with what studies tested.
Evidence Score
59
Good
Price
$21.99
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Compare others in SupplementsTop research
The strongest studies behind this product
Ranked by evidence hierarchy and how closely each study matches this product. Start with the strongest study, then read down. Every claim needs a trail.
Vitamin B12: integrative metabolism and a comparative pharmacological analysis of the four forms of cobalamin: Cyanocobalamin, hydroxocobalamin, methylcobalamin and adenosylcobalamin: Meta-analysis data: clinical efficacy, pharmacokinetics and tolerability in routine medical practice
Meta Analysis · Cahiers Santé Médecine Thérapeutique · 2026
What the research shows
The likely user benefit should be interpreted cautiously until the full paper is reviewed for the product's most realistic positive benefit for the shopper.
Faculty Opinions recommendation of Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia.
Randomized Controlled Trial · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013
Molecular and cellular effects of vitamin B12 forms on human trophoblast cells in presence of excessive folate
Other · Biomedicine & Pharmacotherapy · 2016
Vitamin B12 Plus Graphene Based Bio-Electrocatalyst for Electroreduction of Halocarbons in 1-Butyl-3-Methylimidazolium Tetrafluoroborate: A Special Use of the Synergism between Graphene, Ionic Liquid and Vitamin B12
Other · Russian Journal of Electrochemistry · 2021
Faculty Opinions recommendation of Vitamin B12 and folate and the risk of anemia in old age: the Leiden 85-Plus Study.
Other · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
Scores reflect these cited studies, not medical advice. Expand the full evidence detail below for protocols, dose context, and reported side effects.
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Claim ledger
Every claim, mapped to its source
Each product claim below is tied to a specific paper with study type, match strength, and limitations. Nothing here is medical advice — it is a research trail you can audit.
Claim match reflects how closely a specific paper supports this benefit — not AI confidence or medical certainty.
Full evidence detail
Study-by-study breakdown
Each paper below is ranked for this listing. Start with the highest match, then expand any study for a plain-language readout.
How to read this section
- Match % - how closely the study matches this product (not overall scientific quality).
- Evidence type - study design (RCT, review, etc.) and whether it is direct, category-level, or indirect.
- What it found - short summary and quoted extract from the paper metadata. Not medical advice.
In plain language
What the study reported
Verified extract — not AI generated
“The likely user benefit should be interpreted cautiously until the full paper is reviewed for the product's most realistic positive benefit for the shopper.”
Use context could not be reliably extracted from metadata alone and should be verified during curation.
Safety details should be checked against the full paper and the product's actual use instructions.
Caveats
This fallback uses metadata ranking and should be upgraded with full AI or manual review before stronger claims.
Transparency
Score history
Human review is pending for this listing.
Reviews
Shopper feedback
4.5
average rating
5,379 Amazon reviews were available from the listing metadata.